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1.
Morphine-like activity of some N-substituted amides of met-enkephalin.
Raghubir, R; Patnaik, G K; Dhotre, B J; Mathur, K B; Dhar, M M; Dhawan, B N.
Indian J Exp Biol ; 1989 Sep; 27(9): 826-8
Article in English | IMSEAR | ID: sea-58304

ABSTRACT

Opioid activity of a homologous series of met-enkephalin alkylamides was analysed. In guinea pig ileum test, the hexylamide derivative was most active, whereas the isopropylamide derivative was most potent in analgesia test. The results suggest that structural changes of this type at the C-terminus of the pentapeptide improve the opioid activity.


Subject(s)
Amides , Animals , Chemical Phenomena , Chemistry , Enkephalin, Methionine/pharmacology , Guinea Pigs , Ileum/drug effects , Morphine/pharmacology
2.
Synthesis of substitute enzymes.
Mathur, K B; Dhar, M M.
Hindustan Antibiot Bull ; 1978 Feb-May; 20(3-4): 99-104
Article in English | IMSEAR | ID: sea-2376

Subject(s)
Muramidase/chemical synthesis , Peptide Fragments/chemical synthesis , Ribonucleases/chemical synthesis
3.
A study of anti-semliki forest virus activity of poly N epsilon-(2-aryl-2-thiazoline-4-carbonyl-L-lysines) in mice.
Kant, R; Chandra, K; Gupta, B M; Mathur, K B; Kishore, V; Dhar, M M.
Article in English | IMSEAR | ID: sea-18457

Subject(s)
Animals , Arbovirus Infections/prevention & control , Female , Male , Mice , Peptides/therapeutic use , Phenols/therapeutic use , Polylysine/analogs & derivatives , Semliki forest virus , Structure-Activity Relationship , Thiazoles/therapeutic use
4.
A cyclic tetrapeptide with antiimplantation activity.
Mathur, K B; Rishi, S; Dhar, M M; Kamboj, V P; Kar, A B.
Indian J Exp Biol ; 1974 Mar; 12(2): 199-200
Article in English | IMSEAR | ID: sea-56118

Subject(s)
Animals , Depression, Chemical , Embryo Implantation/drug effects , Female , Peptides, Cyclic/pharmacology , Pregnancy , Rats
5.
Synthesis of poly(Glu-Ala-Ala-Ala-Ser) and poly(Ala-Ala-Glu-Ala-Ser) as model receptors for acetylcholine.
Chakravarty, P K; Mathur, K B; Dhar, M M.
Indian J Biochem Biophys ; 1973 Dec; 10(4): 233-8
Article in English | IMSEAR | ID: sea-27009

Subject(s)
Acetylcholine , Chemical Phenomena , Chemistry , Dimethylformamide , Molecular Conformation , Optical Rotation , Peptides/chemical synthesis , Receptors, Cholinergic
6.
A mechanism for the distinction of foreign proteins by living systems based on peptide directed RNA synthesis.
Dhar, M M; Agrawal, A K; Mathur, K B; Ray, C.
Indian J Biochem Biophys ; 1973 Sep; 10(3): 227-8
Article in English | IMSEAR | ID: sea-27374

Subject(s)
Adenine/metabolism , Animals , Carbon Radioisotopes , Cells, Cultured , Immunologic Memory , Peptides , Proteins , RNA/biosynthesis , Rabbits , Spleen/metabolism
7.
Screening of Indian plants for biological activity. IV.
Dhar, M L; Dhar, M M; Dhawan, B N; Mehrotra, B N; Srimal, R C; Tandon, J S.
Indian J Exp Biol ; 1973 Jan; 11(1): 43-54
Article in English | IMSEAR | ID: sea-57549

Subject(s)
Animals , Culture Techniques , Drug Evaluation, Preclinical , Humans , India , Methanol , Mice , Plant Extracts/pharmacology , Plants , Plants, Medicinal
8.
Effect of endogenous interferon on growth of malignant tumours in man.
Babbar, O P; Dhar, M M; Kar, A B; Mistra, S C; Goel, T C.
Indian J Exp Biol ; 1971 Oct; 9(4): 504-6
Article in English | IMSEAR | ID: sea-61804

Subject(s)
Breast Neoplasms/drug therapy , Humans , Interferons/therapeutic use , Mouth Neoplasms/drug therapy , Neoplasm Regression, Spontaneous , Neoplasms/drug therapy , RNA Viruses , Skin Neoplasms/drug therapy
9.
Screening of Indian plants for biological activity. 3.
Bhakuni, D S; Dhar, M L; Dhar, M M; Dhawan, B N; Gupta, B; Srimal, R C.
Indian J Exp Biol ; 1971 Jan; 9(1): 91-102
Article in English | IMSEAR | ID: sea-59367

Subject(s)
Animals , Anti-Inflammatory Agents , Antihypertensive Agents , Antineoplastic Agents , Diuretics , India , Mice , Pharmacology , Plants, Medicinal
10.
Screening of Indian plants for biological activity. II.
Bhakuni, D S; Dhar, M L; Dhar, M M; Dhawan, B N; Mehrotra, B N.
Indian J Exp Biol ; 1969 Oct; 7(4): 250-62
Article in English | IMSEAR | ID: sea-59493

Subject(s)
Animals , Anti-Bacterial Agents , Anti-Infective Agents , Anti-Inflammatory Agents , Hypolipidemic Agents/therapeutic use , Diuretics , India , Male , Mice , Plant Extracts/therapeutic use , Plants , Rabbits , Rats , Reserpine/antagonists & inhibitors
11.
Screening of Indian plants for biological activity: I.
Dhar, M L; Dhar, M M; Dhawan, B N; Mehrotra, B N; Ray, C.
Indian J Exp Biol ; 1968 Oct; 6(4): 232-47
Article in English | IMSEAR | ID: sea-61473

Subject(s)
Animals , Anti-Infective Agents , Antineoplastic Agents , Cats , Dogs , Guinea Pigs , Humans , Hypoglycemic Agents , India , Mice , Plant Extracts/pharmacology , Plants , Rats
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